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{{f5samples
{{f5samples
|ancestors_in_anatomy_facet=UBERON:0000061,UBERON:0000062,UBERON:0000465,UBERON:0000467,UBERON:0000468,UBERON:0000479,UBERON:0000480,UBERON:0000922,UBERON:0000923,UBERON:0000926,UBERON:0001062,UBERON:0001434,UBERON:0001474,UBERON:0002050,UBERON:0002204,UBERON:0002384,UBERON:0002532,UBERON:0004120,UBERON:0004765,UBERON:0005423
|DRA_sample_Accession=CAGE@SAMD00005731
|ancestors_in_cell_lineage_facet=CL:0000000,CL:0000003,CL:0000004,CL:0000012,CL:0000034,CL:0000035,CL:0000048,CL:0000055,CL:0000062,CL:0000063,CL:0000134,CL:0000144,CL:0000219,CL:0000255,CL:0000335,CL:0000375,CL:0000548,CL:0000723,CL:0002320,CL:0002371
|DRA_sample_Accession_RNASeq=sRNA-Seq@SAMD00005731
|accession_numbers=CAGE;DRX008602;DRR009474;DRZ000899;DRZ002284;DRZ012249;DRZ013634
|accession_numbers_RNASeq=sRNA-Seq;DRX037314;DRR041680;DRZ007322
|ancestors_in_anatomy_facet=UBERON:0000468,UBERON:0001474,UBERON:0002384,UBERON:0000479,UBERON:0000062,UBERON:0000061,UBERON:0000465,UBERON:0000467,UBERON:0001062,UBERON:0000480,UBERON:0004765,UBERON:0002204,UBERON:0001434
|ancestors_in_cell_lineage_facet=CL:0000000,CL:0000055,CL:0000003,CL:0000548,CL:0002320,CL:0002371,CL:0000255,CL:0000062
|ancestors_in_disease_facet=
|ancestors_in_disease_facet=
|ancestors_in_ff_facet=FF:0000102,FF:0000003,FF:0000210,FF:0000101,FF:0000001,FF:0000350,FF:0000344,FF:0000332,FF:0100971,FF:0100385,FF:0100407,FF:0000593
|comment=A3  T0
|comment=A3  T0
|created_by=
|created_by=
|creation_date=
|creation_date=
|data_phase=2
|datafreeze_phase=2
|def=
|def=
|donor= biol_rep3 (A3 T0)
|expression_enrichment_score=chr6:45296048..45296082,+!p1@RUNX2!2.31!229.87!RUNX2;;chr12:53730126..53730146,-!p1@SP7!2.15!138.70!SP7;;chr12:53730147..53730177,-!p2@SP7!2.12!131.27!SP7;;chr7:96654133..96654150,-!p1@DLX5!2.00!99.09!DLX5;;chr2:200322654..200322707,-!p2@SATB2!1.88!107.67!SATB2;;chr5:88178983..88179012,-!p1@MEF2C!1.76!413.54!MEF2C;;chr17:48072574..48072597,-!p1@DLX3!1.74!54.29!DLX3;;chr6:45296191..45296203,+!p13@RUNX2!1.65!43.32!RUNX2;;chr1:25291475..25291511,-!p2@RUNX3!1.56!35.64!RUNX3;;chr2:172967621..172967637,-!p1@DLX2!1.51!81.44!DLX2;;chr1:54204818..54204870,-!p@chr1:54204818..54204870,-!1.50!32.34!GLIS1;;chrX:82763292..82763317,+!p1@POU3F4!1.49!30.12!POU3F4;;chr11:46299199..46299233,+!p1@CREB3L1!1.43!130.94!CREB3L1;;chr9:132427883..132427951,+!p2@PRRX2!1.41!25.00!PRRX2;;chrX:2418949..2419024,-!p1@DHRSX,p1@ZBED1!1.37!22.28!ZBED1;;chr1:151032860..151032918,+!p1@MLLT11!1.32!227.73!MLLT11;;chr12:54410664..54410684,+!p1@HOXC4,p1@HOXC5,p1@HOXC6!1.32!19.72!HOXC5;;chr12:53730178..53730189,-!p3@SP7!1.31!19.31!SP7;;chr1:151032922..151032951,+!p2@MLLT11!1.26!28.05!MLLT11;;chr3:157824001..157824078,-!p2@SHOX2!1.25!16.67!SHOX2;;chr9:132427972..132428056,+!p1@PRRX2!1.24!21.45!PRRX2;;chrX:57619083..57619113,+!p1@ZXDB!1.24!16.25!ZXDB;;chr8:77593474..77593612,+!p1@ZFHX4!1.17!58.25!ZFHX4;;chr1:180199393..180199426,+!p1@LHX4!1.17!13.70!LHX4;;chr8:116681409..116681431,-!p2@TRPS1!1.15!36.22!TRPS1;;chr2:121493425..121493474,+!p1@GLI2!1.15!29.13!GLI2;;chr2:200323414..200323455,-!p1@SATB2!1.12!26.24!SATB2;;chr7:27205136..27205164,-!p1@HOXA9!1.10!11.63!HOXA9;;chr11:63684602..63684664,-!p1@RCOR2!1.09!22.61!RCOR2;;chr3:157823517..157823562,-!p1@SHOX2!1.08!11.80!SHOX2;;chr5:88179017..88179046,-!p2@MEF2C!1.07!43.65!MEF2C;;chr12:53729546..53729565,-!p4@SP7!1.07!10.81!SP7;;chr8:77593448..77593471,+!p2@ZFHX4!1.06!10.40!ZFHX4;;chr6:85474299..85474324,-!p1@TBX18!1.04!17.82!TBX18;;chr5:134369905..134369972,-!p1@PITX1!1.03!14.93!PITX1;;chr7:96635178..96635181,+!p1@DLX6!1.03!9.82!DLX6;;chr9:126774018..126774055,+!p1@LHX2!1.03!9.82!LHX2;;chrX:57936237..57936264,-!p1@ZXDA!1.03!9.74!ZXDA;;chr2:200322229..200322251,-!p3@SATB2!1.02!9.49!SATB2;;chr7:27224842..27224872,-!p1@HOXA11!1.02!9.41!HOXA11;;chr5:133450365..133450444,+!p1@TCF7!1.01!42.57!TCF7;;chr2:145277640..145277771,-!p1@ZEB2!1.00!123.52!ZEB2;;chr17:46682321..46682362,-!p1@HOXB6!1.00!8.91!HOXB6;;chr2:121493492..121493537,+!p2@GLI2!0.99!14.77!GLI2;;chr18:76739816..76739822,+!p1@SALL3!0.99!8.66!SALL3;;chr5:321810..321877,+!p1@AHRR!0.98!27.64!AHRR;;chr7:35293685..35293718,-!p1@TBX20!0.98!8.58!TBX20;;chr7:27205106..27205134,-!p2@HOXA9!0.97!8.33!HOXA9;;chr17:48046881..48046905,+!p5@DLX4!0.97!8.33!DLX4;;chr17:48046642..48046667,+!p3@DLX4!0.97!8.25!DLX4;;chr7:96654026..96654061,-!p2@DLX5!0.95!7.84!DLX5;;chr6:45296266..45296277,+!p34@RUNX2!0.93!7.59!RUNX2;;chr7:27196267..27196311,-!p1@HOXA7!0.93!7.51!HOXA7;;chr11:44331576..44331650,-!p1@ALX4!0.93!7.43!ALX4;;chr5:3595977..3595999,+!p1@IRX1!0.92!7.34!IRX1;;chr5:88185134..88185147,-!p15@MEF2C!0.92!7.34!MEF2C;;chr5:3595934..3595957,+!p2@IRX1!0.91!7.10!IRX1;;chr5:72744594..72744609,-!p1@FOXD1!0.90!33.17!FOXD1;;chr17:46622440..46622477,-!p5@HOXB2!0.90!7.92!HOXB2;;chr7:96634878..96634900,+!p2@DLX6!0.90!6.93!DLX6;;chr7:27192185..27192209,-!p1@HOXA3!0.89!6.68!HOXA3;;chr2:172950227..172950249,+!p2@DLX1!0.89!6.68!DLX1;;chr6:20402102..20402152,+!p1@E2F3!0.88!28.22!E2F3;;chr8:145669791..145669834,-!p1@TONSL!0.88!19.55!TONSL;;chr3:114343826..114343869,-!p4@ZBTB20!0.88!13.78!ZBTB20;;chr1:23857325..23857416,-!p2@E2F2!0.88!7.76!E2F2;;chrX:82763265..82763283,+!p2@POU3F4!0.88!6.60!POU3F4;;chr12:53729525..53729541,-!p5@SP7!0.88!6.52!SP7;;chr1:23857698..23857733,-!p1@E2F2!0.87!12.29!E2F2;;chr20:22565185..22565223,-!p3@FOXA2!0.87!6.35!FOXA2;;chr9:124976328..124976372,-!p2@LHX6!0.87!6.35!LHX6;;chr17:48046543..48046575,+!p2@DLX4!0.87!6.35!DLX4;;chr6:31126291..31126399,+!p1@TCF19!0.86!63.37!TCF19;;chr2:200322723..200322739,-!p6@SATB2!0.86!6.27!SATB2;;chr2:42721205..42721307,+!p4@MTA3!0.86!6.19!MTA3;;chr9:114287433..114287513,+!p1@ZNF483!0.84!16.09!ZNF483;;chr6:85473156..85473210,-!p2@TBX18!0.84!7.26!TBX18;;chr19:58095501..58095535,+!p1@ZIK1!0.83!21.53!ZIK1;;chrX:84499081..84499115,+!p2@ZNF711!0.83!8.75!ZNF711;;chr19:38720294..38720348,-!p1@DPF1!0.83!7.34!DPF1;;chr6:45296028..45296034,+!p24@RUNX2!0.83!5.78!RUNX2;;chr3:114343870..114343887,-!p9@ZBTB20!0.82!5.61!ZBTB20;;chr16:54964740..54964789,+!p1@IRX5!0.81!8.17!IRX5;;chr6:28321909..28321965,-!p3@ZNF323!0.81!5.53!ZNF323;;chr7:27213893..27213954,-!p1@HOXA10!0.81!5.53!HOXA10;;chr12:54393880..54393962,+!p1@HOXC9!0.81!5.45!HOXC9;;chr2:200320768..200320800,-!p4@SATB2!0.81!5.45!SATB2;;chr20:39317868..39317884,-!p1@MAFB!0.80!67.91!MAFB;;chr8:124286775..124286860,-!p2@ZHX1!0.80!24.92!ZHX1;;chr5:174151553..174151610,+!p1@MSX2!0.80!9.16!MSX2;;chr2:176973498..176973524,+!p1@HOXD10!0.80!5.28!HOXD10;;chr19:58111241..58111292,+!p1@ZNF530!0.79!18.89!ZNF530;;chr2:71127699..71127744,+!p1@VAX2!0.79!11.30!VAX2;;chr11:4629953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Line 34: Line 44:
|fonse_treatment_closure=EFO:0000369,FF:0000332,FF:0000593,FF:12858-137D5
|fonse_treatment_closure=EFO:0000369,FF:0000332,FF:0000593,FF:12858-137D5
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|hg19fasta=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.timecourse.hCAGE/Saos-2%2520osteosarcoma%2520treated%2520with%2520ascorbic%2520acid%2520and%2520BGP%2520to%2520induce%2520calcification%252c%252000hr00min%252c%2520biol_rep3%2520%2528A3%2520T0%2529.CNhs12952.12858-137D5.hg19.nobarcode.rdna.fa.gz
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|hg38ctss=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.timecourse.hCAGE/Saos-2%2520osteosarcoma%2520treated%2520with%2520ascorbic%2520acid%2520and%2520BGP%2520to%2520induce%2520calcification%252c%252000hr00min%252c%2520biol_rep3%2520%2528A3%2520T0%2529.CNhs12952.12858-137D5.hg38.nobarcode.ctss.bed.gz
|id=FF:12858-137D5
|id=FF:12858-137D5
|is_a=EFO:0002091;;FF:0000210;;FF:0000593
|is_a=EFO:0002091;;FF:0000593
|name=Saos-2 osteosarcoma treated with ascorbic acid and BGP to induce calcification, 00hr00min, biol_rep3 (A3 T0)
|is_obsolete=
|library_id=CNhs12952
|library_id_phase_based=2:CNhs12952
|microRNAs=
|microRNAs_nn=
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|microRNAs_nonnovel_srna=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2016/vis_viewer/#/human#srna;sample;SRhi10065.GTTTCG.12858
|microRNAs_novel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer_novel/#/human#cage;sample;12858
|microRNAs_novel_srna=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2016/vis_viewer_novel/#/human#srna;sample;SRhi10065.GTTTCG.12858
|name=Saos-2 osteosarcoma treated with ascorbic acid and BGP to induce calcification
|namespace=FANTOM5
|namespace=FANTOM5
|part_of=
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|profile_hcage=CNhs12952,LSID980,release012,COMPLETED
|profile_hcage=CNhs12952,LSID980,release012,COMPLETED
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|rna_box=137
|rna_box=137
|rna_catalog_number=
|rna_catalog_number=
Line 54: Line 81:
|rna_sample_type=
|rna_sample_type=
|rna_tube_id=137D5
|rna_tube_id=137D5
|rna_weight_ug=5.30
|rna_weight_ug=5.3
|rnaseq_library_id=SRhi10065.GTTTCG
|sample_age=
|sample_age=
|sample_category=time courses
|sample_cell_catalog=
|sample_cell_catalog=
|sample_cell_line=Saos-2
|sample_cell_line=Saos-2
Line 68: Line 97:
|sample_ethnicity=
|sample_ethnicity=
|sample_experimental_condition=Saos-2 osteosarcoma treated with ascorbic acid and BGP to induce calcification
|sample_experimental_condition=Saos-2 osteosarcoma treated with ascorbic acid and BGP to induce calcification
|sample_gostat=GO:0044464;cell part;0!GO:0005622;intracellular;0!GO:0044424;intracellular part;2.99725714113972e-284!GO:0043226;organelle;3.25508452983611e-244!GO:0043229;intracellular organelle;1.18608385463022e-243!GO:0043231;intracellular membrane-bound organelle;1.61840221414748e-240!GO:0043227;membrane-bound organelle;2.3699517861528e-240!GO:0044422;organelle part;3.01382597196463e-168!GO:0005737;cytoplasm;9.40701335869204e-168!GO:0044446;intracellular organelle part;7.08342068451035e-167!GO:0005634;nucleus;7.20649772166886e-125!GO:0032991;macromolecular complex;1.98986666392916e-117!GO:0044444;cytoplasmic part;2.76366648527656e-114!GO:0044238;primary metabolic process;3.10036025610477e-108!GO:0044237;cellular metabolic process;2.52537891567828e-105!GO:0043170;macromolecule metabolic process;6.14784637258393e-104!GO:0044428;nuclear part;7.20801054624836e-94!GO:0030529;ribonucleoprotein complex;6.2149451132636e-88!GO:0043233;organelle lumen;3.94234360093879e-83!GO:0031974;membrane-enclosed lumen;3.94234360093879e-83!GO:0003723;RNA binding;4.47224961719245e-80!GO:0005515;protein binding;1.67996690380534e-75!GO:0043283;biopolymer metabolic process;8.15219028756629e-74!GO:0006139;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;9.81578102977853e-68!GO:0016043;cellular component organization and biogenesis;1.15270952455316e-62!GO:0043234;protein complex;1.69048423340126e-62!GO:0005739;mitochondrion;2.05195411958006e-60!GO:0010467;gene expression;2.76410096194381e-60!GO:0006396;RNA processing;8.29252557379442e-59!GO:0031981;nuclear lumen;3.45293617928058e-55!GO:0006259;DNA metabolic process;1.19216695677488e-48!GO:0005840;ribosome;4.2385147819088e-48!GO:0031090;organelle membrane;6.95915308037827e-48!GO:0003676;nucleic acid binding;1.72700086184275e-46!GO:0043228;non-membrane-bound organelle;1.90555835384493e-46!GO:0043232;intracellular non-membrane-bound organelle;1.90555835384493e-46!GO:0016071;mRNA metabolic process;5.0433967090271e-46!GO:0006412;translation;1.18006136316311e-45!GO:0006996;organelle organization and biogenesis;3.62653202344691e-44!GO:0031967;organelle envelope;4.29854289028051e-44!GO:0033036;macromolecule localization;7.44095170452104e-44!GO:0031975;envelope;8.1545807897625e-44!GO:0044429;mitochondrial part;1.88496102857219e-43!GO:0015031;protein transport;1.56783810164385e-42!GO:0003735;structural constituent of ribosome;1.76243791845308e-41!GO:0008380;RNA splicing;2.0242595900294e-41!GO:0019538;protein metabolic process;2.29637768890313e-41!GO:0046907;intracellular transport;8.36212112566268e-41!GO:0006397;mRNA processing;3.08094857782224e-40!GO:0008104;protein localization;4.63092198901711e-39!GO:0007049;cell cycle;9.23634076178381e-39!GO:0065003;macromolecular complex assembly;7.25644324178245e-38!GO:0045184;establishment of protein localization;8.76355147028596e-38!GO:0005654;nucleoplasm;3.33641104862907e-36!GO:0044260;cellular macromolecule metabolic process;5.38951784620627e-36!GO:0044267;cellular protein metabolic process;2.66683977759524e-35!GO:0009058;biosynthetic process;3.18955418248467e-35!GO:0044249;cellular biosynthetic process;9.41922509485611e-35!GO:0016070;RNA metabolic process;2.3153906259033e-34!GO:0033279;ribosomal subunit;2.9786211156969e-34!GO:0009059;macromolecule biosynthetic process;2.99155913133888e-33!GO:0022607;cellular component assembly;5.74412804216842e-33!GO:0006886;intracellular protein transport;1.37426710576346e-32!GO:0022613;ribonucleoprotein complex biogenesis and assembly;1.92460813545669e-32!GO:0005829;cytosol;1.40772401272026e-31!GO:0000166;nucleotide binding;1.92694853957741e-31!GO:0005681;spliceosome;7.6281928489764e-30!GO:0005694;chromosome;1.9602005939196e-29!GO:0044451;nucleoplasm part;1.98642007035451e-28!GO:0006974;response to DNA damage stimulus;2.15226823105417e-28!GO:0005740;mitochondrial envelope;2.18030380205022e-28!GO:0022402;cell cycle process;5.29880798877471e-28!GO:0031966;mitochondrial membrane;1.77473906904957e-27!GO:0019866;organelle inner membrane;5.87832079398815e-27!GO:0000278;mitotic cell cycle;9.30358075960122e-27!GO:0051649;establishment of cellular localization;2.01488200986246e-26!GO:0051641;cellular localization;3.89734239525921e-26!GO:0006281;DNA repair;1.5418018197982e-25!GO:0044427;chromosomal part;5.11876633142272e-25!GO:0005830;cytosolic ribosome (sensu Eukaryota);5.88084894214547e-25!GO:0016462;pyrophosphatase activity;8.11396580853621e-25!GO:0016818;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;8.75276259081467e-25!GO:0016817;hydrolase activity, acting on acid anhydrides;1.086719827277e-24!GO:0005743;mitochondrial inner membrane;1.88026802910278e-24!GO:0017111;nucleoside-triphosphatase activity;3.84879449627309e-24!GO:0051276;chromosome organization and biogenesis;4.643325568808e-23!GO:0032553;ribonucleotide binding;1.13782173234132e-22!GO:0032555;purine ribonucleotide binding;1.13782173234132e-22!GO:0022403;cell cycle phase;1.38120098469195e-22!GO:0006512;ubiquitin cycle;2.00163528315767e-22!GO:0051301;cell division;4.46252275638339e-22!GO:0000087;M phase of mitotic cell cycle;6.93658760077009e-22!GO:0016874;ligase activity;1.3237645867102e-21!GO:0007067;mitosis;1.41935221340264e-21!GO:0017076;purine nucleotide binding;1.58177172063981e-21!GO:0006119;oxidative phosphorylation;6.67635739290736e-21!GO:0006260;DNA replication;9.30464647219099e-21!GO:0051603;proteolysis involved in cellular protein catabolic process;1.92986196020288e-20!GO:0005524;ATP binding;1.97301695230592e-20!GO:0032559;adenyl ribonucleotide binding;2.77594066470715e-20!GO:0019941;modification-dependent protein catabolic process;3.57841525686326e-20!GO:0043632;modification-dependent macromolecule catabolic process;3.57841525686326e-20!GO:0044445;cytosolic part;5.78769482418147e-20!GO:0044455;mitochondrial membrane part;7.12168233622478e-20!GO:0006511;ubiquitin-dependent protein catabolic process;8.5868678250017e-20!GO:0044257;cellular protein catabolic process;8.81600458407071e-20!GO:0012505;endomembrane system;9.51167951086429e-20!GO:0000279;M phase;3.03935816855031e-19!GO:0044265;cellular macromolecule catabolic process;5.50910881555586e-19!GO:0030554;adenyl nucleotide binding;6.9466811158509e-19!GO:0009719;response to endogenous stimulus;2.06249831952348e-18!GO:0022618;protein-RNA complex assembly;2.19279537529652e-18!GO:0005730;nucleolus;2.19279537529652e-18!GO:0015935;small ribosomal subunit;2.54080499920824e-18!GO:0031980;mitochondrial lumen;3.73144270526144e-18!GO:0005759;mitochondrial matrix;3.73144270526144e-18!GO:0006457;protein folding;8.99539018314053e-18!GO:0006325;establishment and/or maintenance of chromatin architecture;1.13388723792195e-17!GO:0043285;biopolymer catabolic process;1.579721098671e-17!GO:0006323;DNA packaging;5.19221812306402e-17!GO:0015934;large ribosomal subunit;5.34997726047136e-17!GO:0031965;nuclear membrane;6.58807758228031e-17!GO:0006605;protein targeting;1.33766634026778e-16!GO:0008135;translation factor activity, nucleic acid binding;1.47270028551602e-16!GO:0000502;proteasome complex (sensu Eukaryota);1.90795351859774e-16!GO:0048770;pigment granule;3.1418502746158e-16!GO:0042470;melanosome;3.1418502746158e-16!GO:0005635;nuclear envelope;3.33603624058421e-16!GO:0016887;ATPase activity;5.35420679632169e-16!GO:0016655;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor;6.0573494461394e-16!GO:0030163;protein catabolic process;7.8148942344954e-16!GO:0005746;mitochondrial respiratory chain;1.06296470698732e-15!GO:0009057;macromolecule catabolic process;1.20319346836483e-15!GO:0000398;nuclear mRNA splicing, via spliceosome;1.53149634795135e-15!GO:0000375;RNA splicing, via transesterification reactions;1.53149634795135e-15!GO:0000377;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;1.53149634795135e-15!GO:0008134;transcription factor binding;1.66946562362919e-15!GO:0042623;ATPase activity, coupled;5.37062818006577e-15!GO:0044453;nuclear membrane part;5.86382975742855e-15!GO:0042254;ribosome biogenesis and assembly;6.24989163844308e-15!GO:0044248;cellular catabolic process;1.21936512552021e-14!GO:0050136;NADH dehydrogenase (quinone) activity;1.29401872220334e-14!GO:0003954;NADH dehydrogenase activity;1.29401872220334e-14!GO:0008137;NADH dehydrogenase (ubiquinone) activity;1.29401872220334e-14!GO:0016604;nuclear body;1.64817556482087e-14!GO:0043412;biopolymer modification;1.81112635203172e-14!GO:0005783;endoplasmic reticulum;1.81744272251837e-14!GO:0004386;helicase activity;2.5688516812926e-14!GO:0006913;nucleocytoplasmic transport;3.86374968483391e-14!GO:0048193;Golgi vesicle transport;6.09387221912797e-14!GO:0015630;microtubule cytoskeleton;6.98002209938395e-14!GO:0051169;nuclear transport;1.18490636449706e-13!GO:0005843;cytosolic small ribosomal subunit (sensu Eukaryota);1.42325915633119e-13!GO:0051726;regulation of cell cycle;2.22940838377153e-13!GO:0000074;regulation of progression through cell cycle;2.49720176375507e-13!GO:0044432;endoplasmic reticulum part;2.70333845087036e-13!GO:0005761;mitochondrial ribosome;2.72327056956279e-13!GO:0000313;organellar ribosome;2.72327056956279e-13!GO:0006333;chromatin assembly or disassembly;2.80578138640369e-13!GO:0050657;nucleic acid transport;4.47396499207864e-13!GO:0051236;establishment of RNA localization;4.47396499207864e-13!GO:0050658;RNA transport;4.47396499207864e-13!GO:0006403;RNA localization;5.07841784393835e-13!GO:0051186;cofactor metabolic process;6.363002436846e-13!GO:0065004;protein-DNA complex assembly;7.92643986244673e-13!GO:0000785;chromatin;1.15416075933007e-12!GO:0005643;nuclear pore;1.33508729877612e-12!GO:0042775;organelle ATP synthesis coupled electron transport;1.35624490921583e-12!GO:0042773;ATP synthesis coupled electron transport;1.35624490921583e-12!GO:0030964;NADH dehydrogenase complex (quinone);1.70888397866992e-12!GO:0045271;respiratory chain complex I;1.70888397866992e-12!GO:0005747;mitochondrial respiratory chain complex I;1.70888397866992e-12!GO:0005794;Golgi apparatus;1.99801157283847e-12!GO:0006464;protein modification process;2.00875721095767e-12!GO:0016651;oxidoreductase activity, acting on NADH or NADPH;3.1919545573205e-12!GO:0051082;unfolded protein binding;3.26402899991817e-12!GO:0006120;mitochondrial electron transport, NADH to ubiquinone;4.32192073829192e-12!GO:0003743;translation initiation factor activity;4.64930158184954e-12!GO:0016192;vesicle-mediated transport;4.67150034832753e-12!GO:0008026;ATP-dependent helicase activity;6.02173247487759e-12!GO:0000775;chromosome, pericentric region;6.94091435600964e-12!GO:0065002;intracellular protein transport across a membrane;7.54536493298291e-12!GO:0006399;tRNA metabolic process;7.65364554268749e-12!GO:0005842;cytosolic large ribosomal subunit (sensu Eukaryota);7.69662990249249e-12!GO:0006261;DNA-dependent DNA replication;7.8615232569915e-12!GO:0043687;post-translational protein modification;1.00593196289702e-11!GO:0016607;nuclear speck;1.09043733140851e-11!GO:0008639;small protein conjugating enzyme activity;1.4157512003678e-11!GO:0015931;nucleobase, nucleoside, nucleotide and nucleic acid transport;1.50595163974576e-11!GO:0050794;regulation of cellular process;1.99609468385457e-11!GO:0016568;chromatin modification;2.12279232655942e-11!GO:0004842;ubiquitin-protein ligase activity;4.38978644108164e-11!GO:0006366;transcription from RNA polymerase II promoter;6.06224874023538e-11!GO:0006413;translational initiation;7.36454707657783e-11!GO:0016879;ligase activity, forming carbon-nitrogen bonds;7.74104704643727e-11!GO:0008565;protein transporter activity;7.84323841209711e-11!GO:0051028;mRNA transport;8.27550677592209e-11!GO:0006461;protein complex assembly;8.5998189131898e-11!GO:0006732;coenzyme metabolic process;1.53400279044023e-10!GO:0006364;rRNA processing;1.58899468460182e-10!GO:0019787;small conjugating protein ligase activity;1.85405496214076e-10!GO:0019222;regulation of metabolic process;2.47432173198176e-10!GO:0009259;ribonucleotide metabolic process;3.8279178182853e-10!GO:0005819;spindle;4.25867976414393e-10!GO:0017038;protein import;4.44431215487142e-10!GO:0016072;rRNA metabolic process;4.94926384067422e-10!GO:0046930;pore complex;5.2758450687352e-10!GO:0006163;purine nucleotide metabolic process;6.39855382908703e-10!GO:0006446;regulation of translational initiation;7.11803735410259e-10!GO:0042175;nuclear envelope-endoplasmic reticulum network;8.03781825953433e-10!GO:0016881;acid-amino acid ligase activity;1.31552087858084e-09!GO:0046961;hydrogen ion transporting ATPase activity, rotational mechanism;1.46646841573094e-09!GO:0006334;nucleosome assembly;2.15181916824592e-09!GO:0005789;endoplasmic reticulum membrane;2.46006481252235e-09!GO:0003697;single-stranded DNA binding;2.48715485840634e-09!GO:0043566;structure-specific DNA binding;3.03149276010425e-09!GO:0031497;chromatin assembly;4.24523553085324e-09!GO:0030532;small nuclear ribonucleoprotein complex;4.75574410566127e-09!GO:0009150;purine ribonucleotide metabolic process;5.23489268504334e-09!GO:0003712;transcription cofactor activity;5.25319968606664e-09!GO:0005813;centrosome;6.69987555745201e-09!GO:0016876;ligase activity, forming aminoacyl-tRNA and related compounds;7.84485135389296e-09!GO:0004812;aminoacyl-tRNA ligase activity;7.84485135389296e-09!GO:0016875;ligase activity, forming carbon-oxygen bonds;7.84485135389296e-09!GO:0009055;electron carrier activity;8.89830511995377e-09!GO:0048475;coated membrane;9.65919277775763e-09!GO:0030117;membrane coat;9.65919277775763e-09!GO:0006164;purine nucleotide biosynthetic process;1.04216641399372e-08!GO:0009141;nucleoside triphosphate metabolic process;1.23002907997172e-08!GO:0000075;cell cycle checkpoint;1.32457303871315e-08!GO:0051329;interphase of mitotic cell cycle;1.35056358719259e-08!GO:0009260;ribonucleotide biosynthetic process;1.39417676916638e-08!GO:0009199;ribonucleoside triphosphate metabolic process;1.57903941973225e-08!GO:0016779;nucleotidyltransferase activity;1.64875313751824e-08!GO:0046933;hydrogen ion transporting ATP synthase activity, rotational mechanism;1.64875313751824e-08!GO:0005815;microtubule organizing center;1.97739550000429e-08!GO:0005667;transcription factor complex;2.06068139637399e-08!GO:0016740;transferase activity;2.09249563065385e-08!GO:0032446;protein modification by small protein conjugation;2.16019033757234e-08!GO:0043038;amino acid activation;2.18238518290223e-08!GO:0006418;tRNA aminoacylation for protein translation;2.18238518290223e-08!GO:0043039;tRNA aminoacylation;2.18238518290223e-08!GO:0005793;ER-Golgi intermediate compartment;2.48818017057512e-08!GO:0007051;spindle organization and biogenesis;2.87775880200662e-08!GO:0016567;protein ubiquitination;3.05182155984715e-08!GO:0009205;purine ribonucleoside triphosphate metabolic process;3.61730098151812e-08!GO:0009144;purine nucleoside triphosphate metabolic process;3.61730098151812e-08!GO:0006350;transcription;3.63826230858734e-08!GO:0031323;regulation of cellular metabolic process;5.02233039536425e-08!GO:0046034;ATP metabolic process;5.39521433150361e-08!GO:0051325;interphase;5.59214019679558e-08!GO:0009060;aerobic respiration;6.5429947426578e-08!GO:0009152;purine ribonucleotide biosynthetic process;8.4726876827238e-08!GO:0015986;ATP synthesis coupled proton transport;8.57927054580055e-08!GO:0015985;energy coupled proton transport, down electrochemical gradient;8.57927054580055e-08!GO:0055086;nucleobase, nucleoside and nucleotide metabolic process;8.73214981362071e-08!GO:0016591;DNA-directed RNA polymerase II, holoenzyme;1.12189807450612e-07!GO:0051170;nuclear import;1.14419388835795e-07!GO:0009056;catabolic process;1.23283994861455e-07!GO:0006888;ER to Golgi vesicle-mediated transport;1.27817482031622e-07!GO:0050789;regulation of biological process;1.28257553728856e-07!GO:0030120;vesicle coat;1.89805752370765e-07!GO:0030662;coated vesicle membrane;1.89805752370765e-07!GO:0006606;protein import into nucleus;2.46849395941537e-07!GO:0003682;chromatin binding;2.54047802608165e-07!GO:0005657;replication fork;2.86209344010588e-07!GO:0045333;cellular respiration;3.05012547418192e-07!GO:0000151;ubiquitin ligase complex;3.07695189097572e-07!GO:0009142;nucleoside triphosphate biosynthetic process;3.57516640395782e-07!GO:0009201;ribonucleoside triphosphate biosynthetic process;3.57516640395782e-07!GO:0000245;spliceosome assembly;3.80038480622234e-07!GO:0007005;mitochondrion organization and biogenesis;5.53507176044425e-07!GO:0019829;cation-transporting ATPase activity;5.66405467705192e-07!GO:0044431;Golgi apparatus part;6.00392637610204e-07!GO:0008094;DNA-dependent ATPase activity;6.11070567259061e-07!GO:0015078;hydrogen ion transmembrane transporter activity;6.39357954576446e-07!GO:0031324;negative regulation of cellular metabolic process;6.9227422687528e-07!GO:0031202;RNA splicing factor activity, transesterification mechanism;7.38940196733257e-07!GO:0009206;purine ribonucleoside triphosphate biosynthetic process;8.12734507704501e-07!GO:0009145;purine nucleoside triphosphate biosynthetic process;8.12734507704501e-07!GO:0016772;transferase activity, transferring phosphorus-containing groups;8.4555601984876e-07!GO:0016469;proton-transporting two-sector ATPase complex;9.96514399154481e-07!GO:0006099;tricarboxylic acid cycle;9.96514399154481e-07!GO:0046356;acetyl-CoA catabolic process;9.96514399154481e-07!GO:0043623;cellular protein complex assembly;9.96514399154481e-07!GO:0005768;endosome;9.96514399154481e-07!GO:0012501;programmed cell death;1.08119700189787e-06!GO:0005798;Golgi-associated vesicle;1.09641826211104e-06!GO:0006754;ATP biosynthetic process;1.14084586914653e-06!GO:0006753;nucleoside phosphate metabolic process;1.14084586914653e-06!GO:0051188;cofactor biosynthetic process;1.3357694564188e-06!GO:0045786;negative regulation of progression through cell cycle;1.35663337087513e-06!GO:0019219;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;1.38602270315967e-06!GO:0006915;apoptosis;1.41016674465476e-06!GO:0003677;DNA binding;1.62834555280896e-06!GO:0003924;GTPase activity;1.76248691761451e-06!GO:0007059;chromosome segregation;1.82308441604423e-06!GO:0032774;RNA biosynthetic process;1.93713568619756e-06!GO:0005839;proteasome core complex (sensu Eukaryota);2.02638495696499e-06!GO:0010468;regulation of gene expression;2.02882450074382e-06!GO:0006302;double-strand break repair;2.2154632643246e-06!GO:0045259;proton-transporting ATP synthase complex;2.48890576273151e-06!GO:0003899;DNA-directed RNA polymerase activity;2.49578842972063e-06!GO:0009117;nucleotide metabolic process;2.72647535658799e-06!GO:0004298;threonine endopeptidase activity;2.91940520098845e-06!GO:0006351;transcription, DNA-dependent;2.94218158698872e-06!GO:0006752;group transfer coenzyme metabolic process;3.15638789194272e-06!GO:0006084;acetyl-CoA metabolic process;3.7483906841456e-06!GO:0006793;phosphorus metabolic process;3.84968190091298e-06!GO:0006796;phosphate metabolic process;3.84968190091298e-06!GO:0048523;negative regulation of cellular process;4.17842242456177e-06!GO:0016363;nuclear matrix;4.18467612939141e-06!GO:0005788;endoplasmic reticulum lumen;4.37967655895832e-06!GO:0005874;microtubule;4.60746355609357e-06!GO:0045934;negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;4.73573966778414e-06!GO:0051168;nuclear export;5.38027212810625e-06!GO:0009109;coenzyme catabolic process;5.38180942711436e-06!GO:0051427;hormone receptor binding;6.49872168686845e-06!GO:0006613;cotranslational protein targeting to membrane;6.49872168686845e-06!GO:0008219;cell death;7.71698638359431e-06!GO:0016265;death;7.71698638359431e-06!GO:0003724;RNA helicase activity;7.78409185583751e-06!GO:0009892;negative regulation of metabolic process;8.40363113149842e-06!GO:0051052;regulation of DNA metabolic process;8.53671935240755e-06!GO:0009108;coenzyme biosynthetic process;8.99532740180407e-06!GO:0051246;regulation of protein metabolic process;9.50136831478101e-06!GO:0030867;rough endoplasmic reticulum membrane;9.73994091817309e-06!GO:0051187;cofactor catabolic process;1.0846174178811e-05!GO:0016310;phosphorylation;1.09559069435311e-05!GO:0008654;phospholipid biosynthetic process;1.10619730524894e-05!GO:0006310;DNA recombination;1.3939990204006e-05!GO:0000776;kinetochore;1.44224099923859e-05!GO:0035257;nuclear hormone receptor binding;1.5852715124287e-05!GO:0007010;cytoskeleton organization and biogenesis;2.22894039623276e-05!GO:0006357;regulation of transcription from RNA polymerase II promoter;2.67624692909177e-05!GO:0015077;monovalent inorganic cation transmembrane transporter activity;2.71962995273794e-05!GO:0005905;coated pit;2.7928665585385e-05!GO:0019899;enzyme binding;3.18587770175842e-05!GO:0006414;translational elongation;4.12073768664057e-05!GO:0007093;mitotic cell cycle checkpoint;4.2757061691785e-05!GO:0003713;transcription coactivator activity;4.35994947147839e-05!GO:0045449;regulation of transcription;4.66319953631609e-05!GO:0016853;isomerase activity;5.28580289570632e-05!GO:0015980;energy derivation by oxidation of organic compounds;6.03398002206623e-05!GO:0044452;nucleolar part;6.03398002206623e-05!GO:0016787;hydrolase activity;6.0810268240887e-05!GO:0016481;negative regulation of transcription;6.25131843084227e-05!GO:0005762;mitochondrial large ribosomal subunit;6.41700799731973e-05!GO:0000315;organellar large ribosomal subunit;6.41700799731973e-05!GO:0006383;transcription from RNA polymerase III promoter;6.56918190477818e-05!GO:0030530;heterogeneous nuclear ribonucleoprotein complex;6.75088649193412e-05!GO:0016563;transcription activator activity;7.18867452403713e-05!GO:0000139;Golgi membrane;7.63123585689314e-05!GO:0007088;regulation of mitosis;7.95030913716769e-05!GO:0043021;ribonucleoprotein binding;8.24475775606851e-05!GO:0043284;biopolymer biosynthetic process;8.24475775606851e-05!GO:0015631;tubulin binding;9.44075916230917e-05!GO:0008033;tRNA processing;9.53221250991299e-05!GO:0007052;mitotic spindle organization and biogenesis;9.54496189267969e-05!GO:0003690;double-stranded DNA binding;0.000104262739757296!GO:0003684;damaged DNA binding;0.000111195500669372!GO:0030118;clathrin coat;0.000111326697427369!GO:0000082;G1/S transition of mitotic cell cycle;0.000117356475669651!GO:0003678;DNA helicase activity;0.000123015575332592!GO:0000059;protein import into nucleus, docking;0.000125469736722616!GO:0048519;negative regulation of biological process;0.000146905797246941!GO:0044440;endosomal part;0.000189297141354905!GO:0010008;endosome membrane;0.000189297141354905!GO:0000228;nuclear chromosome;0.000201811342874469!GO:0031968;organelle outer membrane;0.000209700219099026!GO:0003755;peptidyl-prolyl cis-trans isomerase activity;0.000214251112418835!GO:0031988;membrane-bound vesicle;0.000218122785905185!GO:0007017;microtubule-based process;0.000222610756590902!GO:0045454;cell redox homeostasis;0.000226427021062653!GO:0005791;rough endoplasmic reticulum;0.000243586793032126!GO:0008022;protein C-terminus binding;0.000246523443079576!GO:0005525;GTP binding;0.000246523443079576!GO:0003729;mRNA binding;0.000252734337250162!GO:0016023;cytoplasmic membrane-bound vesicle;0.000253394715387198!GO:0006355;regulation of transcription, DNA-dependent;0.000254160954592847!GO:0016859;cis-trans isomerase activity;0.000267539510407066!GO:0008186;RNA-dependent ATPase activity;0.000271076635264927!GO:0006352;transcription initiation;0.00028283574376272!GO:0006839;mitochondrial transport;0.000288813123016364!GO:0006612;protein targeting to membrane;0.000301848489993264!GO:0016564;transcription repressor activity;0.000307165168063016!GO:0000786;nucleosome;0.00031647033750926!GO:0006275;regulation of DNA replication;0.00032041633213126!GO:0003714;transcription corepressor activity;0.000350953316751619!GO:0019867;outer membrane;0.000351922698527977!GO:0000314;organellar small ribosomal subunit;0.000425130338109284!GO:0005763;mitochondrial small ribosomal subunit;0.000425130338109284!GO:0005770;late endosome;0.000456547020416971!GO:0046489;phosphoinositide biosynthetic process;0.000471668060282115!GO:0006338;chromatin remodeling;0.000480963515931544!GO:0005753;mitochondrial proton-transporting ATP synthase complex;0.000481885782737492!GO:0005741;mitochondrial outer membrane;0.00050660194154246!GO:0046474;glycerophospholipid biosynthetic process;0.000514195567088455!GO:0008250;oligosaccharyl transferase complex;0.000533926866433662!GO:0005885;Arp2/3 protein complex;0.000534647208296387!GO:0000049;tRNA binding;0.0005419788577786!GO:0005769;early endosome;0.000544938754534796!GO:0031252;leading edge;0.000553202563318788!GO:0045261;proton-transporting ATP synthase complex, catalytic core F(1);0.000554573140654391!GO:0030658;transport vesicle membrane;0.000604721302649336!GO:0016126;sterol biosynthetic process;0.000639939961210181!GO:0031982;vesicle;0.000648656978963468!GO:0016741;transferase activity, transferring one-carbon groups;0.000676776283713974!GO:0004579;dolichyl-diphosphooligosaccharide-protein glycotransferase activity;0.000724770136204121!GO:0005684;U2-dependent spliceosome;0.000726094864400349!GO:0008092;cytoskeletal protein binding;0.000727219525919142!GO:0004576;oligosaccharyl transferase activity;0.000738009282852981!GO:0042625;ATPase activity, coupled to transmembrane movement of ions;0.000773179659973338!GO:0004004;ATP-dependent RNA helicase activity;0.000773627037395545!GO:0016790;thiolester hydrolase activity;0.000814257880600157!GO:0008168;methyltransferase activity;0.000836376552307269!GO:0007050;cell cycle arrest;0.000840603972753302!GO:0004527;exonuclease activity;0.000850563699247821!GO:0006402;mRNA catabolic process;0.000866319041290693!GO:0031072;heat shock protein binding;0.000869348596797222!GO:0019783;small conjugating protein-specific protease activity;0.000892351370312241!GO:0031124;mRNA 3'-end processing;0.000915043098835115!GO:0032508;DNA duplex unwinding;0.000915043098835115!GO:0032392;DNA geometric change;0.000915043098835115!GO:0031410;cytoplasmic vesicle;0.000918434141244101!GO:0051789;response to protein stimulus;0.000949848814469076!GO:0006986;response to unfolded protein;0.000949848814469076!GO:0033116;ER-Golgi intermediate compartment membrane;0.000960820952123134!GO:0004843;ubiquitin-specific protease activity;0.000967454121246949!GO:0048500;signal recognition particle;0.00106636769691794!GO:0033178;proton-transporting two-sector ATPase complex, catalytic domain;0.00115892753935565!GO:0030660;Golgi-associated vesicle membrane;0.00117351823576537!GO:0005637;nuclear inner membrane;0.00119337135544764!GO:0000922;spindle pole;0.00120193907865915!GO:0004674;protein serine/threonine kinase activity;0.00120244205699154!GO:0005876;spindle microtubule;0.00120984442008623!GO:0042393;histone binding;0.00120984442008623!GO:0043596;nuclear replication fork;0.0012358260072639!GO:0006611;protein export from nucleus;0.00126482378452428!GO:0006626;protein targeting to mitochondrion;0.00127319905177113!GO:0003746;translation elongation factor activity;0.00133206210731359!GO:0030880;RNA polymerase complex;0.00136795154930212!GO:0032561;guanyl ribonucleotide binding;0.0014095501014108!GO:0019001;guanyl nucleotide binding;0.0014095501014108!GO:0009165;nucleotide biosynthetic process;0.00141200155729377!GO:0000079;regulation of cyclin-dependent protein kinase activity;0.00142742866811872!GO:0000819;sister chromatid segregation;0.00142890443321368!GO:0004221;ubiquitin thiolesterase activity;0.00144551465145583!GO:0006268;DNA unwinding during replication;0.00154768218541087!GO:0065007;biological regulation;0.00154926532214333!GO:0005852;eukaryotic translation initiation factor 3 complex;0.00155357784943061!GO:0005048;signal sequence binding;0.00159952692781788!GO:0030133;transport vesicle;0.00161360673288306!GO:0000287;magnesium ion binding;0.00161360673288306!GO:0008312;7S RNA binding;0.00161695473527923!GO:0006405;RNA export from nucleus;0.00167635071421946!GO:0000226;microtubule cytoskeleton organization and biogenesis;0.00169209422848482!GO:0030176;integral to endoplasmic reticulum membrane;0.00169545613905837!GO:0006695;cholesterol biosynthetic process;0.00175131096112708!GO:0051087;chaperone binding;0.00176822970901162!GO:0016251;general RNA polymerase II transcription factor activity;0.0017913123213308!GO:0043681;protein import into mitochondrion;0.001792063562037!GO:0005838;proteasome regulatory particle (sensu Eukaryota);0.00192224800636989!GO:0042981;regulation of apoptosis;0.00192836362018021!GO:0051539;4 iron, 4 sulfur cluster binding;0.00196650284075945!GO:0000070;mitotic sister chromatid segregation;0.00196660836231418!GO:0043067;regulation of programmed cell death;0.00196660836231418!GO:0048471;perinuclear region of cytoplasm;0.00199133122037104!GO:0006270;DNA replication initiation;0.00206983828305467!GO:0016679;oxidoreductase activity, acting on diphenols and related substances as donors;0.00233471761102889!GO:0016681;oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor;0.00233471761102889!GO:0008121;ubiquinol-cytochrome-c reductase activity;0.00233471761102889!GO:0018196;peptidyl-asparagine modification;0.0023677961487129!GO:0018279;protein amino acid N-linked glycosylation via asparagine;0.0023677961487129!GO:0009112;nucleobase metabolic process;0.00237274790247087!GO:0006144;purine base metabolic process;0.00243987918845635!GO:0005786;signal recognition particle, endoplasmic reticulum targeting;0.00260916201431542!GO:0046467;membrane lipid biosynthetic process;0.0029051808768741!GO:0055029;nuclear DNA-directed RNA polymerase complex;0.00296782214517274!GO:0000428;DNA-directed RNA polymerase complex;0.00296782214517274!GO:0008097;5S rRNA binding;0.00301333747761425!GO:0000910;cytokinesis;0.00303005930303388!GO:0035258;steroid hormone receptor binding;0.0030386075814817!GO:0030663;COPI coated vesicle membrane;0.00305828859097181!GO:0030126;COPI vesicle coat;0.00305828859097181!GO:0015405;P-P-bond-hydrolysis-driven transmembrane transporter activity;0.0030849888455091!GO:0015399;primary active transmembrane transporter activity;0.0030849888455091!GO:0006891;intra-Golgi vesicle-mediated transport;0.00314917145151467!GO:0043601;nuclear replisome;0.00314917145151467!GO:0030894;replisome;0.00314917145151467!GO:0046483;heterocycle metabolic process;0.0031768102416146!GO:0030521;androgen receptor signaling pathway;0.00329707519808828!GO:0043069;negative regulation of programmed cell death;0.00329841841078762!GO:0006614;SRP-dependent cotranslational protein targeting to membrane;0.00330112191099131!GO:0045047;protein targeting to ER;0.00330112191099131!GO:0031123;RNA 3'-end processing;0.00335311394157458!GO:0042802;identical protein binding;0.00358920846864109!GO:0007006;mitochondrial membrane organization and biogenesis;0.00363849350307081!GO:0030119;AP-type membrane coat adaptor complex;0.00368292776891888!GO:0006401;RNA catabolic process;0.00397518024415457!GO:0006284;base-excision repair;0.00406569765184006!GO:0005773;vacuole;0.00415071031766613!GO:0051287;NAD binding;0.00419427539100164!GO:0030384;phosphoinositide metabolic process;0.00426370523176104!GO:0030134;ER to Golgi transport vesicle;0.00427750716983943!GO:0048487;beta-tubulin binding;0.00447438313840336!GO:0030131;clathrin adaptor complex;0.00450637102786133!GO:0006378;mRNA polyadenylation;0.00455439413585174!GO:0030036;actin cytoskeleton organization and biogenesis;0.00455439413585174!GO:0043066;negative regulation of apoptosis;0.00457378704409387!GO:0045263;proton-transporting ATP synthase complex, coupling factor F(o);0.00471418308392811!GO:0033177;proton-transporting two-sector ATPase complex, proton-transporting domain;0.00471418308392811!GO:0051101;regulation of DNA binding;0.00472711858321531!GO:0009116;nucleoside metabolic process;0.00472711858321531!GO:0051252;regulation of RNA metabolic process;0.00472711858321531!GO:0043123;positive regulation of I-kappaB kinase/NF-kappaB cascade;0.00473051555143698!GO:0019205;nucleobase, nucleoside, nucleotide kinase activity;0.00473051555143698!GO:0016044;membrane organization and biogenesis;0.00473825328275174!GO:0004518;nuclease activity;0.00483781062904508!GO:0016281;eukaryotic translation initiation factor 4F complex;0.00510642889884095!GO:0030132;clathrin coat of coated pit;0.00510652166205479!GO:0006892;post-Golgi vesicle-mediated transport;0.00529780192409895!GO:0006890;retrograde vesicle-mediated transport, Golgi to ER;0.00541689677536303!GO:0046966;thyroid hormone receptor binding;0.00560286571875587!GO:0008017;microtubule binding;0.0056399705240874!GO:0008757;S-adenosylmethionine-dependent methyltransferase activity;0.00566113917102543!GO:0006506;GPI anchor biosynthetic process;0.00570590039047339!GO:0003711;transcription elongation regulator activity;0.00571431409650024!GO:0003702;RNA polymerase II transcription factor activity;0.00577060706264274!GO:0006650;glycerophospholipid metabolic process;0.00596789627953497!GO:0006607;NLS-bearing substrate import into nucleus;0.0063102532546685!GO:0046112;nucleobase biosynthetic process;0.0063102532546685!GO:0019206;nucleoside kinase activity;0.00654664743177941!GO:0008361;regulation of cell size;0.00670444374070579!GO:0006818;hydrogen transport;0.00670444374070579!GO:0000792;heterochromatin;0.00670444374070579!GO:0015992;proton transport;0.00673092967032141!GO:0030518;steroid hormone receptor signaling pathway;0.00687214708155706!GO:0006505;GPI anchor metabolic process;0.0069118467379229!GO:0044454;nuclear chromosome part;0.00709774111471795!GO:0000725;recombinational repair;0.00709774111471795!GO:0000724;double-strand break repair via homologous recombination;0.00709774111471795!GO:0000184;mRNA catabolic process, nonsense-mediated decay;0.00712440325039419!GO:0030127;COPII vesicle coat;0.00756319111275546!GO:0012507;ER to Golgi transport vesicle membrane;0.00756319111275546!GO:0016049;cell growth;0.00757353164157424!GO:0006595;polyamine metabolic process;0.00758912513202235!GO:0006916;anti-apoptosis;0.00765444275451231!GO:0016862;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;0.00767761346882495!GO:0000178;exosome (RNase complex);0.00771743167676126!GO:0004003;ATP-dependent DNA helicase activity;0.00774384639171893!GO:0030137;COPI-coated vesicle;0.00788365304945967!GO:0005832;chaperonin-containing T-complex;0.0078911015638133!GO:0006367;transcription initiation from RNA polymerase II promoter;0.0078911015638133!GO:0043130;ubiquitin binding;0.0078911015638133!GO:0032182;small conjugating protein binding;0.0078911015638133!GO:0008139;nuclear localization sequence binding;0.00794280680597404!GO:0000152;nuclear ubiquitin ligase complex;0.00803707354979682!GO:0006497;protein amino acid lipidation;0.00838017405160375!GO:0051098;regulation of binding;0.00838017405160375!GO:0003923;GPI-anchor transamidase activity;0.00838017405160375!GO:0016255;attachment of GPI anchor to protein;0.00838017405160375!GO:0042765;GPI-anchor transamidase complex;0.00838017405160375!GO:0008610;lipid biosynthetic process;0.00851700531439602!GO:0051540;metal cluster binding;0.00900890405776182!GO:0051536;iron-sulfur cluster binding;0.00900890405776182!GO:0006289;nucleotide-excision repair;0.00906378029263971!GO:0016491;oxidoreductase activity;0.00928179113667157!GO:0009303;rRNA transcription;0.00959166186602616!GO:0051920;peroxiredoxin activity;0.00959889947219485!GO:0008276;protein methyltransferase activity;0.00966483194314926!GO:0045045;secretory pathway;0.00995051718973682!GO:0045892;negative regulation of transcription, DNA-dependent;0.0101776783570934!GO:0000339;RNA cap binding;0.0102155959780997!GO:0007346;regulation of progression through mitotic cell cycle;0.0102900136659205!GO:0005669;transcription factor TFIID complex;0.0106415878003589!GO:0001558;regulation of cell growth;0.0109239194823291!GO:0051053;negative regulation of DNA metabolic process;0.0115690958215484!GO:0045936;negative regulation of phosphate metabolic process;0.0116020949784977!GO:0016584;nucleosome positioning;0.011604701217009!GO:0005853;eukaryotic translation elongation factor 1 complex;0.0117393779243299!GO:0016272;prefoldin complex;0.0117675050816569!GO:0030125;clathrin vesicle coat;0.0120372225962601!GO:0030665;clathrin coated vesicle membrane;0.0120372225962601!GO:0031577;spindle checkpoint;0.0120708832803949!GO:0043122;regulation of I-kappaB kinase/NF-kappaB cascade;0.0120816531534758!GO:0008180;signalosome;0.0123048058533456!GO:0031570;DNA integrity checkpoint;0.0124651026421847!GO:0005862;muscle thin filament tropomyosin;0.0125730115067456!GO:0007021;tubulin folding;0.0125799215600465!GO:0000086;G2/M transition of mitotic cell cycle;0.01270283330385!GO:0007264;small GTPase mediated signal transduction;0.012726701648184!GO:0008408;3'-5' exonuclease activity;0.0129633092857367!GO:0019843;rRNA binding;0.0131806340768611!GO:0042770;DNA damage response, signal transduction;0.0137310459179211!GO:0006091;generation of precursor metabolites and energy;0.0138897585106326!GO:0043022;ribosome binding;0.0139325774138305!GO:0043189;H4/H2A histone acetyltransferase complex;0.0143826285270842!GO:0035267;NuA4 histone acetyltransferase complex;0.0145283834750308!GO:0000323;lytic vacuole;0.0145793461925348!GO:0005764;lysosome;0.0145793461925348!GO:0008287;protein serine/threonine phosphatase complex;0.0147597667927266!GO:0030029;actin filament-based process;0.0149605385896992!GO:0030496;midbody;0.0149605385896992!GO:0016197;endosome transport;0.0157869024736276!GO:0016301;kinase activity;0.0159141507280058!GO:0046822;regulation of nucleocytoplasmic transport;0.0159914508790395!GO:0000726;non-recombinational repair;0.0161294211273577!GO:0044262;cellular carbohydrate metabolic process;0.0161887774222755!GO:0000793;condensed chromosome;0.016510840510843!GO:0030140;trans-Golgi network transport vesicle;0.0173325922208724!GO:0004532;exoribonuclease activity;0.0175332963222279!GO:0016896;exoribonuclease activity, producing 5'-phosphomonoesters;0.0175332963222279!GO:0046128;purine ribonucleoside metabolic process;0.0176750190719976!GO:0042278;purine nucleoside metabolic process;0.0176750190719976!GO:0008536;Ran GTPase binding;0.0180131531206741!GO:0016585;chromatin remodeling complex;0.0181495778105617!GO:0030027;lamellipodium;0.019462846677428!GO:0045893;positive regulation of transcription, DNA-dependent;0.019496663567163!GO:0043492;ATPase activity, coupled to movement of substances;0.0195461168262806!GO:0005663;DNA replication factor C complex;0.0198543264124887!GO:0008286;insulin receptor signaling pathway;0.0198543264124887!GO:0065009;regulation of a molecular function;0.0208869062895663!GO:0005869;dynactin complex;0.0209225301110929!GO:0040029;regulation of gene expression, epigenetic;0.0210617172121006!GO:0006376;mRNA splice site selection;0.0218115996922221!GO:0000389;nuclear mRNA 3'-splice site recognition;0.0218115996922221!GO:0042626;ATPase activity, coupled to transmembrane movement of substances;0.0222705746287325!GO:0000123;histone acetyltransferase complex;0.0226267274115375!GO:0016796;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters;0.0226339699821116!GO:0007249;I-kappaB kinase/NF-kappaB cascade;0.0228793193579734!GO:0016579;protein deubiquitination;0.0229623448128606!GO:0042158;lipoprotein biosynthetic process;0.0229861595110466!GO:0022890;inorganic cation transmembrane transporter activity;0.0235101671602419!GO:0005875;microtubule associated complex;0.0237417703700184!GO:0043631;RNA polyadenylation;0.0237620126094584!GO:0008538;proteasome activator activity;0.0240389053759067!GO:0050681;androgen receptor binding;0.0241639163585213!GO:0016820;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;0.0242061087210134!GO:0003887;DNA-directed DNA polymerase activity;0.0242061087210134!GO:0008234;cysteine-type peptidase activity;0.0244834542276073!GO:0016408;C-acyltransferase activity;0.0246363753575541!GO:0000209;protein polyubiquitination;0.025009520549222!GO:0008270;zinc ion binding;0.0250383043213224!GO:0043161;proteasomal ubiquitin-dependent protein catabolic process;0.0250762378680643!GO:0016676;oxidoreductase activity, acting on heme group of donors, oxygen as acceptor;0.0254488597062213!GO:0015002;heme-copper terminal oxidase activity;0.0254488597062213!GO:0016675;oxidoreductase activity, acting on heme group of donors;0.0254488597062213!GO:0004129;cytochrome-c oxidase activity;0.0254488597062213!GO:0032984;macromolecular complex disassembly;0.0254573989454829!GO:0005658;alpha DNA polymerase:primase complex;0.0254613436269578!GO:0003857;3-hydroxyacyl-CoA dehydrogenase activity;0.0255672579903447!GO:0047485;protein N-terminus binding;0.026410941207202!GO:0003756;protein disulfide isomerase activity;0.0264546694837239!GO:0016864;intramolecular oxidoreductase activity, transposing S-S bonds;0.0264546694837239!GO:0016765;transferase activity, transferring alkyl or aryl (other than methyl) groups;0.0269451326090835!GO:0019752;carboxylic acid metabolic process;0.0270293999626891!GO:0005652;nuclear lamina;0.0270293999626891!GO:0042326;negative regulation of phosphorylation;0.0272409439231455!GO:0043624;cellular protein complex disassembly;0.027407193287377!GO:0050662;coenzyme binding;0.0289843718468992!GO:0009113;purine base biosynthetic process;0.0301157260063548!GO:0006672;ceramide metabolic process;0.0301455373910195!GO:0009304;tRNA transcription;0.0310436049383341!GO:0000096;sulfur amino acid metabolic process;0.0313355289325545!GO:0009451;RNA modification;0.0320274467365878!GO:0006082;organic acid metabolic process;0.0321398589212214!GO:0008156;negative regulation of DNA replication;0.0321398589212214!GO:0005680;anaphase-promoting complex;0.0321398589212214!GO:0000084;S phase of mitotic cell cycle;0.0323662151639298!GO:0005784;translocon complex;0.0327578901809503!GO:0030145;manganese ion binding;0.03320271156514!GO:0044438;microbody part;0.03320271156514!GO:0044439;peroxisomal part;0.03320271156514!GO:0051320;S phase;0.033206854093213!GO:0042791;5S class rRNA transcription;0.033456262868589!GO:0000127;transcription factor TFIIIC complex;0.033456262868589!GO:0042797;tRNA transcription from RNA polymerase III promoter;0.033456262868589!GO:0005850;eukaryotic translation initiation factor 2 complex;0.0339858656424546!GO:0046426;negative regulation of JAK-STAT cascade;0.0348383186997478!GO:0043241;protein complex disassembly;0.0354940854976601!GO:0005665;DNA-directed RNA polymerase II, core complex;0.0355439290378192!GO:0032507;maintenance of cellular protein localization;0.0357849227125013!GO:0031625;ubiquitin protein ligase binding;0.0357998148103746!GO:0006356;regulation of transcription from RNA polymerase I promoter;0.0358183503639436!GO:0006220;pyrimidine nucleotide metabolic process;0.0359102649543943!GO:0005856;cytoskeleton;0.0364128530262386!GO:0042026;protein refolding;0.0364138568516985!GO:0005758;mitochondrial intermembrane space;0.0367938968588355!GO:0022411;cellular component disassembly;0.036803914242627!GO:0000118;histone deacetylase complex;0.0371321580311313!GO:0004347;glucose-6-phosphate isomerase activity;0.037179739402836!GO:0005521;lamin binding;0.0376751635893027!GO:0005938;cell cortex;0.03836347830217!GO:0045792;negative regulation of cell size;0.0386410796417294!GO:0001832;blastocyst growth;0.0387071421885501!GO:0007094;mitotic cell cycle spindle assembly checkpoint;0.039061537444788!GO:0008475;procollagen-lysine 5-dioxygenase activity;0.0394088973311662!GO:0004185;serine carboxypeptidase activity;0.0397154549368974!GO:0032981;mitochondrial respiratory chain complex I assembly;0.0400884211738239!GO:0010257;NADH dehydrogenase complex assembly;0.0400884211738239!GO:0033108;mitochondrial respiratory chain complex assembly;0.0400884211738239!GO:0030522;intracellular receptor-mediated signaling pathway;0.0402084459760325!GO:0000077;DNA damage checkpoint;0.0408405239093511!GO:0001711;endodermal cell fate commitment;0.0411573686042464!GO:0030858;positive regulation of epithelial cell differentiation;0.0411573686042464!GO:0031528;microvillus membrane;0.0411573686042464!GO:0001706;endoderm formation;0.0411573686042464!GO:0007007;inner mitochondrial membrane organization and biogenesis;0.0426157245433401!GO:0009124;nucleoside monophosphate biosynthetic process;0.0426157245433401!GO:0009123;nucleoside monophosphate metabolic process;0.0426157245433401!GO:0004722;protein serine/threonine phosphatase activity;0.0428617288810399!GO:0044450;microtubule organizing center part;0.0430293404470254!GO:0006541;glutamine metabolic process;0.0433588962832691!GO:0006360;transcription from RNA polymerase I promoter;0.0433904430830431!GO:0043550;regulation of lipid kinase activity;0.0436079382317966!GO:0031903;microbody membrane;0.0446494233149579!GO:0005778;peroxisomal membrane;0.0446494233149579!GO:0003725;double-stranded RNA binding;0.0450751148485291!GO:0017134;fibroblast growth factor binding;0.0450919313926971!GO:0007265;Ras protein signal transduction;0.0457624636713102!GO:0006520;amino acid metabolic process;0.0461573823136462!GO:0043488;regulation of mRNA stability;0.0463196813585715!GO:0043487;regulation of RNA stability;0.0463196813585715!GO:0019902;phosphatase binding;0.0463705779187289!GO:0030330;DNA damage response, signal transduction by p53 class mediator;0.0463705779187289!GO:0043433;negative regulation of transcription factor activity;0.0463784158881885!GO:0042769;DNA damage response, detection of DNA damage;0.046548008428332!GO:0032200;telomere organization and biogenesis;0.0469198915774932!GO:0000723;telomere maintenance;0.0469198915774932!GO:0016884;carbon-nitrogen ligase activity, with glutamine as amido-N-donor;0.0473573695119823!GO:0006301;postreplication repair;0.0476139831829374!GO:0030433;ER-associated protein catabolic process;0.0483200452357489!GO:0006515;misfolded or incompletely synthesized protein catabolic process;0.0483200452357489!GO:0001725;stress fiber;0.0483393126545353!GO:0032432;actin filament bundle;0.0483393126545353!GO:0003985;acetyl-CoA C-acetyltransferase activity;0.0488034899731487!GO:0051059;NF-kappaB binding;0.0488334036048716!GO:0031227;intrinsic to endoplasmic reticulum membrane;0.0489347021044574!GO:0046519;sphingoid metabolic process;0.0495223170841041!GO:0030308;negative regulation of cell growth;0.0495674562081338!GO:0016891;endoribonuclease activity, producing 5'-phosphomonoesters;0.0495674562081338!GO:0008143;poly(A) binding;0.0498762433058483
|sample_id=12858
|sample_id=12858
|sample_note=
|sample_note=
Line 74: Line 104:
|sample_strain=
|sample_strain=
|sample_tissue=
|sample_tissue=
|time= 00hr00min
|timecourse=Saos_calcification
|top_motifs=PDX1:3.34856306467;TFDP1:2.00479404236;PITX1..3:1.824789371;VSX1,2:1.82285913951;E2F1..5:1.72389785631;HOX{A4,D4}:1.716375558;NFY{A,B,C}:1.67571996921;PRRX1,2:1.62248633576;ARNT_ARNT2_BHLHB2_MAX_MYC_USF1:1.58047538917;NRF1:1.56915253589;POU1F1:1.50436344848;NKX2-3_NKX2-5:1.49272384955;ZNF143:1.25700381361;FOXA2:1.16285553122;NKX3-1:1.14511895242;GFI1:1.12885732654;YY1:1.09517099654;EN1,2:1.07061535412;FOXP1:1.0156728378;CUX2:0.948017872695;TOPORS:0.938449582549;MEF2{A,B,C,D}:0.923044675382;SOX17:0.906532900886;HIC1:0.893481246557;BREu{core}:0.855944916673;NANOG:0.850730077912;EVI1:0.778542666747;NFIX:0.745257423361;CDC5L:0.734446447709;TGIF1:0.703217365233;HIF1A:0.685538593457;NKX6-1,2:0.678865522454;STAT5{A,B}:0.674982335554;FOXQ1:0.670332603821;NKX2-1,4:0.669600406314;PBX1:0.661003773974;FOX{F1,F2,J1}:0.660523250562;LEF1_TCF7_TCF7L1,2:0.586047309503;MYB:0.571412454823;ELK1,4_GABP{A,B1}:0.534980099618;AHR_ARNT_ARNT2:0.532550309193;PAX2:0.485851803527;HES1:0.480225866788;PAX8:0.479328191766;T:0.465366494983;MZF1:0.450910874129;SOX{8,9,10}:0.437796282483;POU3F1..4:0.43420464522;SREBF1,2:0.429828820965;NFE2L2:0.427215900089;PAX4:0.420114355837;LHX3,4:0.416891272161;ATF4:0.403428585431;SP1:0.403052217796;PAX1,9:0.392490883767;PAX6:0.391211082541;ZNF384:0.372429610305;ZFP161:0.361242305883;ONECUT1,2:0.350796897378;TEAD1:0.285986353564;ATF6:0.28140347985;PAX3,7:0.262952781293;RUNX1..3:0.257816152633;FOX{I1,J2}:0.253274484518;RBPJ:0.234289813922;ZNF423:0.227612989714;FOXD3:0.225584278883;JUN:0.217894192633;MYBL2:0.216530159613;RORA:0.212874688947;DBP:0.202811649965;STAT1,3:0.199142069362;CDX1,2,4:0.19203615022;ZBTB16:0.185904049265;IKZF2:0.149509749605;RREB1:0.141869484314;TFAP2B:0.140333037193;GTF2I:0.140310622128;ATF5_CREB3:0.130102283415;OCT4_SOX2{dimer}:0.125901555075;FOXM1:0.118738886951;NR3C1:0.111556556927;NR1H4:0.0928335710051;HOX{A5,B5}:0.0783543677506;XCPE1{core}:0.0738398069923;POU6F1:0.0462695035528;IKZF1:0.0417631018968;ADNP_IRX_SIX_ZHX:0.0414091331149;TEF:0.0387390161162;EGR1..3:0.032068342969;HOXA9_MEIS1:0.0238284633509;RFX1:0.00943879657165;TBX4,5:-0.000137778184734;CREB1:-0.000451496978721;XBP1:-0.00134397830103;bHLH_family:-0.0139489673546;AIRE:-0.0224114650458;FOXN1:-0.0287028652026;AR:-0.043790796759;HNF1A:-0.0465188614363;RXR{A,B,G}:-0.0611319043853;PATZ1:-0.0720533671655;NFE2:-0.0733327636794;SOX2:-0.0758739656992;NR6A1:-0.0962340579678;ARID5B:-0.110301356634;MYFfamily:-0.116310123681;ESR1:-0.125727331342;ZBTB6:-0.127697781047;NR5A1,2:-0.130756664964;POU5F1:-0.142366460344;MED-1{core}:-0.159446573664;FOSL2:-0.171297911915;MAZ:-0.183419516947;ESRRA:-0.189382400097;ELF1,2,4:-0.190117088793;NHLH1,2:-0.195460615543;ZIC1..3:-0.195906006843;BACH2:-0.209323939154;IRF7:-0.211160920955;PAX5:-0.213658754462;GZF1:-0.216903708285;MTE{core}:-0.217533901855;GATA6:-0.221592995602;CRX:-0.242117461352;PRDM1:-0.247918160764;FOS_FOS{B,L1}_JUN{B,D}:-0.257539168813;RFX2..5_RFXANK_RFXAP:-0.283624140397;FOXP3:-0.284886985002;FOXL1:-0.297984460668;TFAP4:-0.299895327421;GCM1,2:-0.300716633111;DMAP1_NCOR{1,2}_SMARC:-0.304620783907;HLF:-0.308421155361;ZNF238:-0.308811759511;GTF2A1,2:-0.315443915464;EBF1:-0.330110419471;HNF4A_NR2F1,2:-0.330398195349;NKX2-2,8:-0.340440423202;GFI1B:-0.346787471318;REST:-0.36313308099;SOX5:-0.371877598641;NFE2L1:-0.382116561605;SMAD1..7,9:-0.382601114897;TP53:-0.387131061981;RXR{A,B,G}_{NR1H2,PPAR}dimers:-0.388307807188;TLX1..3_NFIC{dimer}:-0.391071528956;ALX4:-0.422732335365;GLI1..3:-0.443035429652;BPTF:-0.454996283265;ZNF148:-0.465552456924;IRF1,2:-0.467708124161;KLF4:-0.47590656397;UFEwm:-0.484715345029;FOX{D1,D2}:-0.522356956836;SPIB:-0.529030118118;NFIL3:-0.529878177035;PPARG:-0.531014924529;MAFB:-0.535299458695;NFKB1_REL_RELA:-0.538148270524;NKX3-2:-0.538761711655;TFCP2:-0.542211894152;SRF:-0.579209151632;SNAI1..3:-0.579754618306;SPI1:-0.622813114415;ATF2:-0.637379662022;ZEB1:-0.673682489895;HAND1,2:-0.675086503799;LMO2:-0.676319754395;SPZ1:-0.680037809295;POU2F1..3:-0.689253809596;HBP1_HMGB_SSRP1_UBTF:-0.706801088756;TAL1_TCF{3,4,12}:-0.71749602553;ETS1,2:-0.720976567806;MYOD1:-0.750290398678;CEBPA,B_DDIT3:-0.758654223828;HOX{A6,A7,B6,B7}:-0.760129837711;MTF1:-0.765491223085;GATA4:-0.768748416423;TFAP2{A,C}:-0.770339822235;ALX1:-0.797282047652;HMX1:-0.812575201483;NANOG{mouse}:-0.863728046227;NFATC1..3:-0.96393133644;STAT2,4,6:-0.969590526198;RXRA_VDR{dimer}:-1.08301928377;TLX2:-1.10367273623;HMGA1,2:-1.11380430917;HSF1,2:-1.15222904573;EP300:-1.19893519348;TBP:-1.27245278536;FOXO1,3,4:-1.37577963964
|top_motifs=PDX1:3.34856306467;TFDP1:2.00479404236;PITX1..3:1.824789371;VSX1,2:1.82285913951;E2F1..5:1.72389785631;HOX{A4,D4}:1.716375558;NFY{A,B,C}:1.67571996921;PRRX1,2:1.62248633576;ARNT_ARNT2_BHLHB2_MAX_MYC_USF1:1.58047538917;NRF1:1.56915253589;POU1F1:1.50436344848;NKX2-3_NKX2-5:1.49272384955;ZNF143:1.25700381361;FOXA2:1.16285553122;NKX3-1:1.14511895242;GFI1:1.12885732654;YY1:1.09517099654;EN1,2:1.07061535412;FOXP1:1.0156728378;CUX2:0.948017872695;TOPORS:0.938449582549;MEF2{A,B,C,D}:0.923044675382;SOX17:0.906532900886;HIC1:0.893481246557;BREu{core}:0.855944916673;NANOG:0.850730077912;EVI1:0.778542666747;NFIX:0.745257423361;CDC5L:0.734446447709;TGIF1:0.703217365233;HIF1A:0.685538593457;NKX6-1,2:0.678865522454;STAT5{A,B}:0.674982335554;FOXQ1:0.670332603821;NKX2-1,4:0.669600406314;PBX1:0.661003773974;FOX{F1,F2,J1}:0.660523250562;LEF1_TCF7_TCF7L1,2:0.586047309503;MYB:0.571412454823;ELK1,4_GABP{A,B1}:0.534980099618;AHR_ARNT_ARNT2:0.532550309193;PAX2:0.485851803527;HES1:0.480225866788;PAX8:0.479328191766;T:0.465366494983;MZF1:0.450910874129;SOX{8,9,10}:0.437796282483;POU3F1..4:0.43420464522;SREBF1,2:0.429828820965;NFE2L2:0.427215900089;PAX4:0.420114355837;LHX3,4:0.416891272161;ATF4:0.403428585431;SP1:0.403052217796;PAX1,9:0.392490883767;PAX6:0.391211082541;ZNF384:0.372429610305;ZFP161:0.361242305883;ONECUT1,2:0.350796897378;TEAD1:0.285986353564;ATF6:0.28140347985;PAX3,7:0.262952781293;RUNX1..3:0.257816152633;FOX{I1,J2}:0.253274484518;RBPJ:0.234289813922;ZNF423:0.227612989714;FOXD3:0.225584278883;JUN:0.217894192633;MYBL2:0.216530159613;RORA:0.212874688947;DBP:0.202811649965;STAT1,3:0.199142069362;CDX1,2,4:0.19203615022;ZBTB16:0.185904049265;IKZF2:0.149509749605;RREB1:0.141869484314;TFAP2B:0.140333037193;GTF2I:0.140310622128;ATF5_CREB3:0.130102283415;OCT4_SOX2{dimer}:0.125901555075;FOXM1:0.118738886951;NR3C1:0.111556556927;NR1H4:0.0928335710051;HOX{A5,B5}:0.0783543677506;XCPE1{core}:0.0738398069923;POU6F1:0.0462695035528;IKZF1:0.0417631018968;ADNP_IRX_SIX_ZHX:0.0414091331149;TEF:0.0387390161162;EGR1..3:0.032068342969;HOXA9_MEIS1:0.0238284633509;RFX1:0.00943879657165;TBX4,5:-0.000137778184734;CREB1:-0.000451496978721;XBP1:-0.00134397830103;bHLH_family:-0.0139489673546;AIRE:-0.0224114650458;FOXN1:-0.0287028652026;AR:-0.043790796759;HNF1A:-0.0465188614363;RXR{A,B,G}:-0.0611319043853;PATZ1:-0.0720533671655;NFE2:-0.0733327636794;SOX2:-0.0758739656992;NR6A1:-0.0962340579678;ARID5B:-0.110301356634;MYFfamily:-0.116310123681;ESR1:-0.125727331342;ZBTB6:-0.127697781047;NR5A1,2:-0.130756664964;POU5F1:-0.142366460344;MED-1{core}:-0.159446573664;FOSL2:-0.171297911915;MAZ:-0.183419516947;ESRRA:-0.189382400097;ELF1,2,4:-0.190117088793;NHLH1,2:-0.195460615543;ZIC1..3:-0.195906006843;BACH2:-0.209323939154;IRF7:-0.211160920955;PAX5:-0.213658754462;GZF1:-0.216903708285;MTE{core}:-0.217533901855;GATA6:-0.221592995602;CRX:-0.242117461352;PRDM1:-0.247918160764;FOS_FOS{B,L1}_JUN{B,D}:-0.257539168813;RFX2..5_RFXANK_RFXAP:-0.283624140397;FOXP3:-0.284886985002;FOXL1:-0.297984460668;TFAP4:-0.299895327421;GCM1,2:-0.300716633111;DMAP1_NCOR{1,2}_SMARC:-0.304620783907;HLF:-0.308421155361;ZNF238:-0.308811759511;GTF2A1,2:-0.315443915464;EBF1:-0.330110419471;HNF4A_NR2F1,2:-0.330398195349;NKX2-2,8:-0.340440423202;GFI1B:-0.346787471318;REST:-0.36313308099;SOX5:-0.371877598641;NFE2L1:-0.382116561605;SMAD1..7,9:-0.382601114897;TP53:-0.387131061981;RXR{A,B,G}_{NR1H2,PPAR}dimers:-0.388307807188;TLX1..3_NFIC{dimer}:-0.391071528956;ALX4:-0.422732335365;GLI1..3:-0.443035429652;BPTF:-0.454996283265;ZNF148:-0.465552456924;IRF1,2:-0.467708124161;KLF4:-0.47590656397;UFEwm:-0.484715345029;FOX{D1,D2}:-0.522356956836;SPIB:-0.529030118118;NFIL3:-0.529878177035;PPARG:-0.531014924529;MAFB:-0.535299458695;NFKB1_REL_RELA:-0.538148270524;NKX3-2:-0.538761711655;TFCP2:-0.542211894152;SRF:-0.579209151632;SNAI1..3:-0.579754618306;SPI1:-0.622813114415;ATF2:-0.637379662022;ZEB1:-0.673682489895;HAND1,2:-0.675086503799;LMO2:-0.676319754395;SPZ1:-0.680037809295;POU2F1..3:-0.689253809596;HBP1_HMGB_SSRP1_UBTF:-0.706801088756;TAL1_TCF{3,4,12}:-0.71749602553;ETS1,2:-0.720976567806;MYOD1:-0.750290398678;CEBPA,B_DDIT3:-0.758654223828;HOX{A6,A7,B6,B7}:-0.760129837711;MTF1:-0.765491223085;GATA4:-0.768748416423;TFAP2{A,C}:-0.770339822235;ALX1:-0.797282047652;HMX1:-0.812575201483;NANOG{mouse}:-0.863728046227;NFATC1..3:-0.96393133644;STAT2,4,6:-0.969590526198;RXRA_VDR{dimer}:-1.08301928377;TLX2:-1.10367273623;HMGA1,2:-1.11380430917;HSF1,2:-1.15222904573;EP300:-1.19893519348;TBP:-1.27245278536;FOXO1,3,4:-1.37577963964
|xref=
|zenbu_report=https://fantom.gsc.riken.jp/zenbu/reports/#miRNA_expression_atlas_human;search_select_hide=table111:FF:12858-137D5;search_select_hide=table117:FF:12858-137D5
}}
}}

Latest revision as of 18:46, 4 June 2020

Name:Saos-2 osteosarcoma treated with ascorbic acid and BGP to induce calcification
Species:Human (Homo sapiens)
Library ID:CNhs12952
Sample type:time courses
Genomic View: UCSC
RefEX:Specific genes
CAGEd-oPOSSUM:link
ZENBU report :link
Additional information
Sample information
strainNA
tissueNA
dev stageNA
sexfemale
ageNA
cell typeosteoblast
cell lineSaos-2
companyNA
collaborationKim Summers (Roslin Institute)
External link for information[{{{sample_info_link}}} {{{sample_info_link}}}]
RNA information
lot numberNA
catalog numberNA
sample typeNA
extraction protocol (Details)OP-RNA-extraction-totalRNA-miRNeasy_Mini-v1.0

CAGE Accession numbers
MethodSample accession id
CAGE  SAMD00005731
Library accession numbers

Library idMethodExp. accession idRun accession id
CNhs12952 CAGE DRX008602 DRR009474
Accession ID Hg19

Library idBAMCTSS
CNhs12952 DRZ000899 DRZ002284
Accession ID Hg38

Library idBAMCTSS
CNhs12952 DRZ012249 DRZ013634
Download raw sequence, BAM & CTSS
Hg19
FastaBAMCTSS
downloaddownloaddonwload
Hg38
BAMCTSS
downloaddonwload

RNA-Seq Accession numbers
MethodSample accession id
sRNA-Seq  SAMD00005731
Library accession numbers

Library idMethodExp. accession idRun accession id
SRhi10065.GTTTCG sRNA-Seq DRX037314 DRR041680
Accession ID Hg19

Library idBAMCTSS
SRhi10065.GTTTCG DRZ007322


Relative expression to median (log10)

Transcription factors with enriched expression in this sampleRanked list of transcription factor promoter expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed.



Co-expression clusters with enriched expression in this sampleRanked list of co-expression cluster expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed. <br>Analyst:NA <br><br>link to dataset.<br>data

Coexpression clusterscore
C0-CD14-Eosinophils-Neutrophils-Basophils-CD34-immature-Peripheral0
C1-testis-epididymis-embryonic-medulla-pituitary-trachea-caudate0
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C82-Basophils-CD14-Eosinophils-Natural-Peripheral-immature-CD340
C83-choriocarcinoma-pancreatic-placenta-chorionic-HES3GFP-testicular-amniotic0
C84-choriocarcinoma-pancreatic-Wilms-Mallassezderived-thymus-salivary-colon0
C85-neuroblastoma-carcinoid-retinoblastoma-small-pineal-rhabdomyosarcoma-medulloblastoma0
C86-colon-carcinoid-small-neuroectodermal-giant-large-neuroepithelioma0
C87-retinoblastoma-left-nonsmall-heart-small-diaphragm-bronchogenic0
C88-Melanocyte-melanoma-Macrophage-Mesenchymal-migratory-Dendritic-Monocytederived0
C89-small-retinoblastoma-medulloblastoma-iPS-acantholytic-eye-bronchogenic0
C9-skeletal-diaphragm-tongue-throat-penis-heart-left0
C90-neuroectodermal-peripheral-neuroepithelioma-neuroblastoma-carcinoid-parietal-putamen0
C91-Fibroblast-Smooth-mesenchymal-Mesothelial-Small-Preadipocyte-Hair0
C92-CD14CD16-CD14-Eosinophils-Basophils-Neutrophils-Macrophage-Whole0
C93-chronic-acute-leukemia-acantholytic-medulloblastoma-testis-papillotubular0
C94-smallcell-adrenal-lung-nonsmall-small-somatostatinoma-teratocarcinoma0
C95-lung-aorta-trachea-penis-Alveolar-throat-endometrioid0
C96-non-acute-tonsil-spleen-Burkitt-lymphoma-appendix0
C97-small-smallcell-gastrointestinal-argyrophil-putamen-duodenum-brain0
C98-CD8-Natural-Basophils-blood-CD4-Peripheral-Whole0
C99-hairy-mycosis-submaxillary-salivary-cord-kidney-parotid0



Repeat families with enriched expression in this sample<b>Summary:</b>Ranked list of repeat family expression in this sample relative tothe median expression in the FANTOM5 collection is shown. Value is log10transformed.<br><b>Analyst:</b>NA<br><br>link to dataset.<br>data



TFBS(DNA)motifs over-represented in proximal region of promoters active in this sample

JASPAR motifs<b>Summary:</b>Association of JASPAR motif to the promoter expression in thissample. Pearson's correlation between the number of TFBSs estimated byusing the position-weight matrix for each promoter and its expression isexpressed as Z-score by taking the ones based on random position-weightmatrix, and the tail probability of the normal distribution correspondingto the Z-score is taken as the resulting P-value. Lower P-value indicatesmore (non-random) association of the motif to promoter expression<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data

library id: CNhs12952

Jaspar motifP-value
MA0002.20.88
MA0003.10.227
MA0004.10.53
MA0006.10.383
MA0007.10.453
MA0009.10.813
MA0014.10.725
MA0017.10.00253
MA0018.20.0101
MA0019.10.718
MA0024.11.50387e-7
MA0025.10.685
MA0027.10.497
MA0028.10.229
MA0029.10.763
MA0030.10.829
MA0031.10.692
MA0035.20.148
MA0038.15.39959e-4
MA0039.20.925
MA0040.10.146
MA0041.10.196
MA0042.10.484
MA0043.10.377
MA0046.10.74
MA0047.20.29
MA0048.10.216
MA0050.10.0466
MA0051.10.423
MA0052.12.65962e-4
MA0055.10.124
MA0057.10.409
MA0058.10.415
MA0059.10.925
MA0060.16.05018e-13
MA0061.10.0188
MA0062.20.284
MA0065.20.00322
MA0066.10.25
MA0067.10.356
MA0068.10.421
MA0069.10.697
MA0070.10.0276
MA0071.10.48
MA0072.10.318
MA0073.10.398
MA0074.10.204
MA0076.10.128
MA0077.10.27
MA0078.10.835
MA0079.20.817
MA0080.22.87398e-9
MA0081.10.0634
MA0083.10.179
MA0084.10.197
MA0087.10.377
MA0088.10.354
MA0090.10.639
MA0091.10.0515
MA0092.10.195
MA0093.10.391
MA0099.22.80924e-4
MA0100.10.239
MA0101.10.0402
MA0102.20.0356
MA0103.10.0239
MA0104.20.352
MA0105.10.00653
MA0106.10.187
MA0107.10.0102
MA0108.20.0632
MA0111.10.841
MA0112.20.00107
MA0113.10.621
MA0114.10.0996
MA0115.10.202
MA0116.10.0176
MA0117.10.461
MA0119.10.145
MA0122.10.632
MA0124.10.624
MA0125.10.0181
MA0131.10.252
MA0135.10.0903
MA0136.11.22422e-7
MA0137.20.144
MA0138.20.0303
MA0139.10.25
MA0140.10.319
MA0141.10.139
MA0142.10.118
MA0143.10.965
MA0144.10.0545
MA0145.10.0971
MA0146.10.0955
MA0147.10.409
MA0148.10.0891
MA0149.10.553
MA0150.10.252
MA0152.10.11
MA0153.10.296
MA0154.10.023
MA0155.10.2
MA0156.10.0212
MA0157.10.15
MA0159.10.0135
MA0160.10.2
MA0162.10.147
MA0163.15.20067e-4
MA0164.10.979
MA0258.10.0481
MA0259.10.29



FANTOM5 phase1 novel unique motifs<b>Summary:</b>Association of the 169 novel and unique motifs discovered in FANTOM5 phase1 in this sample. Among the de-novo motifs discovered by DMF, HOMER,ChIPMunk, and ScanAll, only novel motifs are selected after comparison with known motif sets, and their clustering based on MACRO-APE resulted in169 novel and unique motifs. Their association to the promoter expression is evaluated in the same way to the JASPAR motif above<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data

library id: CNhs12952

Novel motifP-value
10.398
100.888
1000.403
1010.858
1020.539
1030.0209
1040.699
1050.666
1061.99431e-4
1070.0311
1080.607
1090.171
110.112
1100.407
1110.353
1120.023
1130.462
1140.027
1150.135
1160.814
1170.674
1180.427
1190.0757
120.728
1200.21
1210.388
1220.621
1230.975
1240.413
1250.117
1260.254
1270.644
1280.00678
1290.198
130.607
1300.0516
1310.268
1320.311
1330.692
1340.922
1350.108
1360.556
1370.23
1380.663
1390.00354
140.463
1400.235
1410.452
1420.871
1430.0189
1440.514
1450.128
1460.754
1470.838
1480.0655
1490.0935
150.519
1500.545
1510.207
1520.0203
1530.181
1540.614
1550.601
1560.518
1570.463
1580.759
1590.572
160.195
1600.339
1610.941
1620.835
1630.865
1640.664
1650.683
1660.696
1670.0908
1680.151
1690.0335
170.12
180.0704
190.141
20.232
200.287
210.793
220.189
230.0131
240.77
250.935
260.527
270.0227
280.903
290.547
30.104
300.426
310.491
320.0689
330.627
340.334
350.238
360.689
370.136
380.32
390.105
40.432
400.489
410.144
420.326
430.158
440.0168
450.13
460.137
470.355
480.527
490.253
50.388
500.411
510.517
520.148
530.843
540.301
550.078
560.456
570.839
580.185
590.0785
60.492
600.0322
610.987
620.0876
630.161
640.495
650.0233
660.145
670.653
680.602
690.686
70.774
700.00708
710.29
720.0684
730.0511
740.299
750.544
760.698
770.107
780.666
790.00291
80.311
800.197
810.431
820.0257
830.775
840.842
850.00148
860.364
870.699
880.376
890.00809
90.174
900.363
910.402
920.127
930.828
940.0333
950.343
960.414
970.973
980.237
990.524



de novo motifs identified by HOMER in promoters active in this sample<b>Summary:</b>The result of HOMER in this sample is shown.<br><b>Analyst:</b>NA <br> library id: CNhs12952


FANTOM5 (FF) ontology

Direct parent terms


Ancestor terms (non development)<b>Summary:</b>Connected ontology terms with is_a, part_of or located_in relationship <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source data<br>data

CL: Cell type
0000000 (cell), 0000000 (cell)
0000055 (non-terminally differentiated cell)
0000003 (native cell)
0000548 (animal cell)
0002320 (connective tissue cell)
0002371 (somatic cell)
0000255 (eukaryotic cell)
0000062 (osteoblast)

UBERON: Anatomy
0000468 (multi-cellular organism)
0001474 (bone element)
0002384 (connective tissue)
0000479 (tissue)
0000062 (organ)
0000061 (anatomical structure)
0000465 (material anatomical entity)
0000467 (anatomical system)
0001062 (anatomical entity)
0000480 (anatomical group)
0004765 (skeletal element)
0002204 (musculoskeletal system)
0001434 (skeletal system)

FF: FANTOM5
0000102 (sample by type)
0000003 (cell line sample)
0000210 (human sample)
0000101 (sample by species)
0000001 (sample)
0000350 (experimentally modified sample)
0000344 (0 minute sample)
0000332 (calcification induced with ascorbate and BPG sample)
0100971 (SAOS-2 cell sample)
0100385 (bone cancer cell line sample)
0100407 (osteosarcoma cell line sample)
0000593 (human Saos2 osteosarcoma cell line 0min after induction of calcification with ascorbate and BPG sample)

Ancestor terms (development)<b>Summary:</b>Connected ontology terms with develops_from, derives_from or preceded_by relationship <br><b>Analyst:</b> Hideya Kawaji <br><br>link to source data<br>data
CL:0000134 (mesenchymal cell)
CL:0000335 (mesenchyme condensation cell)

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